Amorphous materials possess unique physicochemical properties that offer exciting advantages for pharmaceutical applications. My research focuses on fundamentally understanding molecular relaxation processes using dielectric spectroscopy, paving the way for advanced pharmaceutical formulations in two key areas.
Enhancing Drug Solubility: Many promising drug candidates suffer from poor solubility, leading to low bioavailability. Amorphizing crystalline drugs increases their free energy, significantly boosting solubility. By leveraging fundamental knowledge, I explore polymer-based formulations to optimize amorphous drug stability and efficacy.
Stabilizing Therapeutic Proteins: Therapeutic proteins, including monoclonal antibodies (mAbs), are revolutionizing disease treatment. However, many proteins face stability challenges in solution. Freeze-drying provides solid-state stabilization, with disaccharides playing a critical role in preserving protein structure and biological activity. Understanding molecular mobility is essential in preventing degradation and aggregation. My work focuses on selecting the right excipients to develop stable freeze-dried protein formulations built upon the principles of amorphous science.
Rational design of Amorphous Solid Dispersion using Time-Temperature-Transformation Diagram
Advanced Techniques for the Stabilization of Amorphous Solid Dispersion
Relaxation Processes and Stability of Freeze-dried Protein Formulations
Molecular Mobilities in Amorphous Drugs
